Publications

2025

• Faucher FF, Blažková K,  Lovell S, Bertolini M, Herrero-Bourdieu J, Cosco ED, Bogyo M, Barniol-Xicota M. Macrocyclic phage display for identification of selective protease substrates. J Am Chem Soc. 10.1021/jacs.5c04424
• Oken AC, Turcu AL, Tzortzini E, Georgiou K, Nagel J, Barniol-Xicota M , Kim GR, Lee SD, Kim YC, Müller EC, Kolocouris A, Vázquez S, Mansoor SE.UB-MBX-46 is a potent and selective antagonist of the human P2X7 receptor developed by structure-based drug design. Nature Communications. 2025 (accepted)

2024

• Ji S, Mirayala V, Dohnálek J, Riopedre-Fernandez M, Lepsik M, Van de Plassche M, Vanhoutte R, Barniol-Xicota M, Moreira R, Strisovsky K, Verhelst SHL. 4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL.  ACS Med Chem Lett. 2024
• Waeterschoot J, Barniol-Xicota M, Verhelst S, Baatsen P, Koos E, Lammertyn J, Casadevall i Solvas X. Lipid vesicle formation by encapsulation of SMALPs in surfactant-stabilised droplets. Heliyon, 2024, 10 (18), e37915. doi: 0.1016/j.heliyon.2024.e37915

2023

• Kahler JP, Aloi D, Miedes Aliaga J, Kerselaars S, Voets T, Vriens J, Verhelst SHL, Barniol-Xicota M. Clotrimazole-based modulators of the TRPM3 ion channel reveal narrow structure-activity relationship. ACS Chem Bio. 2023, 18, 3, 456–464. DOI: 10.1021/acschembio.2c00672
• Vanhoutte R, Barniol-Xicota M, Chiu W, Vangeel L, Jochmans D, De Jonghe S, Zidane H, Barr HM, London N, Neyts J, Verhelst SHL. Azapeptide activity-based probes for the SARS-CoV-2 main protease enable visualization of inhibition in infected cells. Chem Sci. 2023 Jan 6;14(7):1666-1672. doi: 10.1039/d2sc04147b.

2022

• Codony S, Entrena JM, Calvó-Tusell C, Jora B, González-Cano R, Osuna S, Corpas R, Morisseau C, Pérez B, Barniol-Xicota M, Griñán-Ferré C, Pérez C, Rodríguez-Franco MI, Martínez AL, Loza MI, Pallàs M, Verhelst SHL, Sanfeliu C, Feixas F, Hammock BD, Brea J, Cobos EJ, Vázquez S. Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors. J Med Chem. 2022 Oct 27;65(20):13660-13680. doi: 10.1021/acs.jmedchem.2c00515

2021

• Barniol-Xicota M. & Verhelst SHL. Lipidomic and in-gel analysis of maleic acid co-polymer-based nanodiscs reveals differences in composition of solubilized membranes. Commun. Biol. 4, 218, 2021.

2020

• van de Plassche MAT*, Barniol-Xicota M*, Verhelst SHL. Peptidyl Acyloxymethyl Ketones as Activity-Based Probes for the Main Protease of SARS-CoV-2. Chembiochem. 2020; doi:10.1002/cbic.202000371. *Shared first-authorship. Journal Cover
• Barniol-Xicota M & Verhelst SHL. Isolation of intramembrane proteases in membrane-like environments. Biochim Biophys Acta Biomembr. 2020;1862(4):183193.

2019

• Beard H A, Barniol-Xicota M, Yang J, Verhelst SHL. Discovery of Cellular Roles of Intramembrane Proteases. ACS Chem Biol. 2019;14(11):2372-2388. doi:10.1021/acschembio.9b00404
• Perez-Areales FJ, Turcu A, Barniol-Xicota M, Pont C, Pivetta D, Espargaró A, Bartolini M, De Simone A, Andrisano V, Pérez B, Sabaté R, Sureda FX, Vázquez S, Muñoz-Torrero D. A novel class of multitarget benzohomoadamantane-chlorotacrine hybrids to confront the cholinergic and glutamatergic mechanisms of Alzheimer’s disease. Eur. J. Med. Chem. 2019 180 613-626.

2018

• Barniol-Xicota M. & Verhelst S. H. L. Functional Rhomboid Proteases in Lipid Nanodiscs by Using Diisobutylene/Maleic Acid Copolymers. J Am Chem Soc 2018 140 44 14557-14561.
• Alonso JM, Quiroga S, Codony S, Turcu AL, Barniol-Xicota M, Pérez D, Guitián E, Vázquez S, Peña D. Palladium-catalyzed Cocyclotrimerization of Arynes with a Pyramidalized Alkene. Chem Comm. 2018 54(47):5996-5999.
• Yang J, Barniol-Xicota M, Nguyen MTN, Ticha A, Strisovsky K, Verhelst SHL. Benzoxazin-4- ones as novel easily accessible inhibitors for rhomboid proteases. Bioorg Med Chem. 2018 28 (8) 1423-1427.
• Karoutzou O, Kwak S-H, Lee S-D, Martínez-Falguera D, Sureda FX, Vázquez S, Kim Y-C, Barniol-Xicota M. Multi-target directed ligands to the NMDA and P2X7 receptors of interest for the treatment of Alzheimer’s disease. Molecules 2018 23(1) 230.
• Leiva R, Barniol-Xicota M, Codony S, Ginex T, Vanderlinden E, Montes M, Caffrey M, Luque FJ, Naesens L, Vázquez S. Aniline-based inhibitors of influenza H1N1 virus acting on hemagglutinin-mediated fusion. J Med Chem. 2018 61(1) 98-118.

2017

• Rao ZX, Patel B, Monaco A, Cao ZJ, Barniol-Xicota M., Pichon E, Ladlow M, Hilton ST. 3D-Printed polypropylene continuous-flow column reactors: exploration of reactor utility in SNAr reactions and the synthesis of bicyclic and tetracyclic heterocycles. Eur J Org Chem. 2017 44 6499-6504.
• Barniol-Xicota M, Gazzarrini S, Torres E, Naesens L, Moroni A, Wang J, Vázquez S. Slow but steady wins the race: dissimilarities among new dual inhibitors of the wild-type and the V27A mutant M2 channels of influenza A virus. J Med Chem. 2017 60(9) 3727-3738.
• Lin C-W, Mensa B, Barniol-Xicota M, DeGrado WF, Gai F. Activation pH and Gating Dynamics of Influenza A M2 Proton Channel Revealed by Single-Molecule Spectroscopy. Angew Chem Int Ed. 2017. 56(19)5283-5287.
• Monaco A, Szulc BR, Rao ZX, Barniol-Xicota M, Sehailia M, Borges B, Hilton S. A Short Total Synthesis of (±)-Lycorane by a Sequential Intramolecular Acylal Cyclisation (IAC) and Intramolecular Heck Addition Reaction. Chemistry. 2017 23(20) 4750-4755.
• Barniol-Xicota M, Kwak S-H, Lee S-D, Caseley E, Valverde E, Kim YC, Vázquez S. Escape from adamantane: scaffold optimization of novel P2X7 antagonists featuring complex polycycles. Bioorg Med Chem Lett. 2017 27 759- 763.

2016

• Zarei M, Barroso E, Leiva R, Barniol-Xicota M, Pujol-Bech E, Escolano C,Vázquez S, Palomer X, Pardo V, González-Rodríguez A, Valverde AM, Quesada T, Villarroya F, Wahli W, Vázquez-Carrera M. Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and is Activated by PPARβ/δ Deficiency. Diabetes. 2016 65(10)3185-99.
• Barniol-Xicota M, Leiva R, Escolano C, Vázquez S. Syntheses of Cinacalcet: An Enantiopure Active Pharmaceutical Ingredient (API). Synthesis 2016. 48 783-803.

2015

• Barniol-Xicota M, Escandell A, Valverde E, Julian E, Torrents E, Vázquez S. Antibacterial activity of novel benzopolycyclic amines. Bioorg Med Chem. 2015 23 290-296.

2014

• Rey-Carrizo M, Barniol-Xicota M, Font-Bardia M, Vázquez S. Dimerization of Pyramidalized 3,4,8 9-Tetramethyltetracyclo [4.4.0.0(3 9).0(4 8)]dec-1(6)-ene to a Hydrocarbon Featuring Four Cyclohexane Rings in Boat Conformations. Angew Chem Int Ed. 2014, 53, 8195-8199.
• Rey-Carrizo M, Barniol-Xicota M, Ma C, Frigolé-Vivas M, Torres E, Naesens L, Llabrés S, Juárez-Jiménez J, Luque FJ, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. Easily Accessible Polycyclic Amines that Inhibit the Wild-Type and Amantadine-Resistant Mutants of the M2 Channel of Influenza A Virus. J Med Chem. 2014. 57(13) 5738-5747.
• Barniol-Xicota M, Turcu AL, Codony S, Escolano C, Vázquez S. Direct reductive alkylation of amine hydrochlorides with aldehyde bisulfite adducts. Tetrahedron Lett. 2014. 55 2548-2550.

2013

• Rey-Carrizo M, Torres E, Ma C, Barniol-Xicota M, Wang J, Wu Y, Naesens L, Degrado WF, Lamb RA, Pinto LH, Vázquez S. 3-Azatetracyclo[5.2.1.1(5 8).0(1 5)]undecane Derivatives: From Wild-Type Inhibitors of the M2 Ion Channel of Influenza A Virus to Derivatives with Potent Activity against the V27A Mutant. J Med Chem. 2013 56(22) 9265-74.